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- Title
Rhodium-catalyzed dynamic kinetic asymmetric transformations of racemic allenes by the [3+2] annulation of aryl ketimines.
- Authors
Tran, Duc N; Cramer, Nicolai
- Abstract
Racemization required: Rhodium(I)-catalyzed C-H activation directed by unprotected ketimines initiates selective [3+2] cycloaddition with allenes, providing access to highly substituted indenylamines. The reaction proceeds through the dynamic kinetic asymmetric transformation of racemic allenes. The catalyst controls the enantio- and diastereoselectivity, the regioselectivities of the C-H activation and allene incorporation, as well as the E/Z ratio.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 40, p10630
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201304919