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- Title
A synthetic riboswitch that operates using a rationally designed ligand-RNA pair.
- Authors
Dohno, Chikara; Kohyama, Izumi; Kimura, Maki; Hagihara, Masaki; Nakatani, Kazuhiko
- Abstract
The construction of an artificial riboswitch is based on a ligand-RNA pair without any molecular biology-based selection processes. The ligand selectively and significantly stabilized an RNA duplex containing an r(XGG)/r(XGG) sequence (X=U, A, G). The integration of the ligand-binding sequences into the 5'-untranslated region of mRNA provided an artificial riboswitch that was responsive to Z-NCTS.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 38, p9976
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201303370