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- Title
The absolute configuration of (+)- and (-)-erythro-mefloquine.
- Authors
Müller, Michael; Orben, Claudia M; Schützenmeister, Nina; Schmidt, Manuel; Leonov, Andrei; Reinscheid, Uwe M; Dittrich, Birger; Griesinger, Christian
- Abstract
The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, whereas the configuration determined by three enantioselective syntheses is wrong.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 23, p6047
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201300258