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- Title
Rhodium(III)-catalyzed alkenyl C-H bond functionalization: convergent synthesis of furans and pyrroles.
- Authors
Lian, Yajing; Huber, Tatjana; Hesp, Kevin D; Bergman, Robert G; Ellman, Jonathan A
- Abstract
Ring in the new: a new annulation for the efficient synthesis of substituted furans and pyrroles is reported. The Rh(III) -catalyzed reaction of O-methyl α,β-unsaturated oximes with aldehydes and N-tosyl imines affords secondary alcohol and amine intermediates, respectively. Cyclization and aromatization occurs under the reaction conditions to provide access to biologically relevant furans and pyrroles in good yields. Cp*=C(5)Me(5), DCE=1,2-dichloroethane, THF=tetrahydrofuran.
- Publication
Angewandte Chemie (International ed. in English), 2013, Vol 52, Issue 2, p629
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201207995