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- Title
Protein tango: the toolbox to capture interacting partners.
- Authors
Rutkowska, Anna; Schultz, Carsten
- Abstract
The evaluation of protein function in the context of the whole cell is crucial for understanding of living systems. In this context, the identification and modulation of protein-protein interactions in and outside cells is of ample importance. Several methods have been developed in the past years to detect and/or actively induce protein-protein interactions in living cells. As a result, tools are now available to manipulate intracellular events by reversible or irreversible cross-linking of proteins in a specific manner. These techniques open many new doors and enable the dissection of complicated protein networks. Herein we describe which cross-linkers and inducers of dimerization are out there and how to make use of this great toolbox.
- Publication
Angewandte Chemie (International ed. in English), 2012, Vol 51, Issue 33, p8166
- ISSN
1521-3773
- Publication type
Journal Article
- DOI
10.1002/anie.201201717