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- Title
Evidence that nuclear factor IA inhibits repair after white matter injury.
- Authors
Fancy, Stephen P J; Glasgow, Stacey M; Finley, Meggie; Rowitch, David H; Deneen, Benjamin
- Abstract
Chronic demyelination can result in axonopathy and is associated with human neurological conditions such as multiple sclerosis (MS) in adults and cerebral palsy in infants. In these disorders, myelin regeneration is inhibited by impaired differentiation of oligodendrocyte progenitors into myelin-producing oligodendrocytes. However, regulatory factors relevant in human myelin disorders and in myelin regeneration remain poorly understood. Here we have investigated the role of the transcription factor nuclear factor IA (NFIA) in oligodendrocyte progenitor differentiation during developmental and regenerative myelination.
- Publication
Annals of neurology, 2012, Vol 72, Issue 2, p224
- ISSN
1531-8249
- Publication type
Journal Article
- DOI
10.1002/ana.23590