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- Title
Solvents and the Risk of Parkinson's Disease.
- Authors
Nirenberg, Melissa J.
- Abstract
Parkinson's disease (PD) has been closely linked to both genetic and environmental factors. In prior studies, environmental exposures associated with PD have included pesticides, well water consumption, and residency in rural areas; inverse risk factors have included smoking and coffee use. Some studies have implicated solvents in PD risk, but data have been lacking about whether (and which) solvents may be involved. In this study, the authors examined the potential association between PD and exposure to six specific solvents. They used a case-control study design, with 99 pairs of twins who were discordant for PD status. Study subjects, all of whom were male, were recruited from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort. Structured questionnaires were used to obtain detailed lifetime occupational and hobby histories from each subject. Expert raters, blinded to PD status, then used this information to infer each subject's lifetime exposure to these six solvents. The authors found that ever exposure to trichloroethylene (TCE) was associated with an increased risk of PD (odds ratio [OR], 6.1; P = 0.034). There also were non-significant trends toward increased PD risk with ever exposure to perchloroethylene (PERC; OR, 10.5; P = 0.053) or carbon tetrachloride (CCl4; OR, 2.3; P = 0.088). There were similar findings when they examined the duration of exposure and cumulative lifetime exposure to these solvents. Based on these findings, the authors conclude that solvents, and TCE in specific, are associated with an increased risk of PD.
- Publication
Neurology Alert, 2012, Vol 30, Issue 6, p41
- ISSN
0741-4234
- Publication type
Academic Journal
- DOI
10.1002/ana.22629