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- Title
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
- Authors
Kaatz, Scott; Kouides, Peter A; Garcia, David A; Spyropolous, Alex C; Crowther, Mark; Douketis, Jim D; Chan, Anthony K C; James, Andra; Moll, Stephan; Ortel, Thomas L; Van Cott, Elizabeth M; Ansell, Jack
- Abstract
The new oral anticoagulants dabigatran, rivaroxaban and apixaban have advantages over warfarin which include no need for laboratory monitoring, less drug-drug interactions and less food-drug interactions. However, there is no established antidote for patients who are bleeding or require emergent surgery and there is a paucity of evidence to guide the clinical care during these situations. Members of thrombosis and anticoagulation groups participating in the Thrombosis and Hemostasis Summit of North America formulated expert opinion guidance for reversing the anticoagulant effect of the new oral anticoagulants and suggest: routine supportive care, activated charcoal if drug ingestion was within a couple of hours, and hemodialysis if feasible for dabigatran. Also, the pros and cons of the possible use of four factor prothrombin complex concentrate are discussed.
- Publication
American journal of hematology, 2012, Vol 87 Suppl 1, pS141
- ISSN
1096-8652
- Publication type
Journal Article
- DOI
10.1002/ajh.23202