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- Title
Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.
- Authors
Moga, Katherine A; Bickford, Lissett R; Geil, Robert D; Dunn, Stuart S; Pandya, Ashish A; Wang, Yapei; Fain, John H; Archuleta, Christine F; O'Neill, Adrian T; Desimone, Joseph M
- Abstract
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.
- Publication
Advanced materials (Deerfield Beach, Fla.), 2013, Vol 25, Issue 36, p5060
- ISSN
1521-4095
- Publication type
Journal Article
- DOI
10.1002/adma.201300526