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- Title
Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells.
- Authors
Chaturvedi, Lakshmi S; Basson, Marc D
- Abstract
Short bowel syndrome occurs when a shortened intestine cannot absorb sufficient nutrients or fluids. Teduglutide is a recombinant analogue of human glucagonlike peptide 2 that reduces dependence on parenteral nutrition in patients with short bowel syndrome by promoting enterocytic proliferation, increasing the absorptive surface area. However, enterocyte function depends not only on the number of cells that are present but also on differentiated features that facilitate nutrient absorption and digestion.
- Publication
JAMA surgery, 2013, Vol 148, Issue 11, p1037
- ISSN
2168-6262
- Publication type
Journal Article
- DOI
10.1001/jamasurg.2013.3731