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- Title
Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial.
- Authors
Krab, Lianne C; de Goede-Bolder, Arja; Aarsen, Femke K; Pluijm, Saskia M F; Bouman, Marlies J; van der Geest, Jos N; Lequin, Maarten; Catsman, Coriene E; Arts, Willem Frans M; Kushner, Steven A; Silva, Alcino J; de Zeeuw, Chris I; Moll, Henriëtte A; Elgersma, Ype
- Abstract
Neurofibromatosis type 1 (NF1) is among the most common genetic disorders that cause learning disabilities. Recently, it was shown that statin-mediated inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase restores the cognitive deficits in an NF1 mouse model.
- Publication
JAMA, 2008, Vol 300, Issue 3, p287
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.300.3.287