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- Title
High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.
- Authors
Aisen, Paul S; Schneider, Lon S; Sano, Mary; Diaz-Arrastia, Ramon; van Dyck, Christopher H; Weiner, Myron F; Bottiglieri, Teodoro; Jin, Shelia; Stokes, Karen T; Thomas, Ronald G; Thal, Leon J; Alzheimer Disease Cooperative Study
- Abstract
Blood levels of homocysteine may be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, homocysteine levels can be reduced by administration of high-dose supplements of folic acid and vitamins B(6) and B(12). Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline.
- Publication
JAMA, 2008, Vol 300, Issue 15, p1774
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.300.15.1774