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- Title
F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome.
- Authors
Masciari, Serena; Van den Abbeele, Annick D; Diller, Lisa R; Rastarhuyeva, Iryna; Yap, Jeffrey; Schneider, Katherine; Digianni, Lisa; Li, Frederick P; Fraumeni, Joseph F, Jr; Syngal, Sapna; Garber, Judy E
- Abstract
Individuals with Li-Fraumeni syndrome (LFS) have an inherited cancer predisposition to a diverse array of malignancies beginning early in life; survivors of one cancer have a markedly elevated risk of additional primary tumors. The underlying genetic defect in the majority of the families is a germline mutation in the TP53 tumor suppressor gene. The diversity of tumors and rarity of families have contributed to the difficulty in devising effective screening recommendations for members of LFS kindreds.
- Publication
JAMA, 2008, Vol 299, Issue 11, p1315
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.299.11.1315