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- Title
Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.
- Authors
Pandharipande, Pratik P; Pun, Brenda T; Herr, Daniel L; Maze, Mervyn; Girard, Timothy D; Miller, Russell R; Shintani, Ayumi K; Thompson, Jennifer L; Jackson, James C; Deppen, Stephen A; Stiles, Renee A; Dittus, Robert S; Bernard, Gordon R; Ely, E Wesley
- Abstract
Lorazepam is currently recommended for sustained sedation of mechanically ventilated intensive care unit (ICU) patients, but this and other benzodiazepine drugs may contribute to acute brain dysfunction, ie, delirium and coma, associated with prolonged hospital stays, costs, and increased mortality. Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction.
- Publication
JAMA, 2007, Vol 298, Issue 22, p2644
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.298.22.2644