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Title
Therapies directed against epidermal growth factor receptor in aerodigestive carcinomas.
Authors
Karamouzis, Michalis V; Grandis, Jennifer R; Argiris, Athanassios
Abstract
Malignancies arising from the aerodigestive epithelium, including lung, head and neck, and esophageal carcinomas, are the leading causes of cancer-related mortality worldwide. Given the biological importance of epidermal growth factor receptor (EGFR) in cancer development and progression, EGFR inhibitors have emerged as promising novel therapies.