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- Title
Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media.
- Authors
Hall-Stoodley, Luanne; Hu, Fen Ze; Gieseke, Armin; Nistico, Laura; Nguyen, Duc; Hayes, Jay; Forbes, Michael; Greenberg, David P; Dice, Bethany; Burrows, Amy; Wackym, P Ashley; Stoodley, Paul; Post, J Christopher; Ehrlich, Garth D; Kerschner, Joseph E
- Abstract
Chronic otitis media (OM) is a common pediatric infectious disease. Previous studies demonstrating that metabolically active bacteria exist in culture-negative pediatric middle-ear effusions and that experimental infection with Haemophilus influenzae in the chinchilla model of otitis media results in the formation of adherent mucosal biofilms suggest that chronic OM may result from a mucosal biofilm infection.
- Publication
JAMA, 2006, Vol 296, Issue 2, p202
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.296.2.202