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- Title
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.
- Authors
Heilbronn, Leonie K; de Jonge, Lilian; Frisard, Madlyn I; DeLany, James P; Larson-Meyer, D Enette; Rood, Jennifer; Nguyen, Tuong; Martin, Corby K; Volaufova, Julia; Most, Marlene M; Greenway, Frank L; Smith, Steven R; Deutsch, Walter A; Williamson, Donald A; Ravussin, Eric; Pennington CALERIE Team
- Abstract
Prolonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans.
- Publication
JAMA, 2006, Vol 295, Issue 13, p1539
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.295.13.1539