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- Title
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
- Authors
Morris, Claudia R; Kato, Gregory J; Poljakovic, Mirjana; Wang, Xunde; Blackwelder, William C; Sachdev, Vandana; Hazen, Stanley L; Vichinsky, Elliott P; Morris, Sidney M, Jr; Gladwin, Mark T
- Abstract
Sickle cell disease is characterized by a state of nitric oxide resistance and limited bioavailability of l-arginine, the substrate for nitric oxide synthesis. We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary hypertension, and patient outcomes.
- Publication
JAMA, 2005, Vol 294, Issue 1, p81
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.294.1.81