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- Title
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease.
- Authors
Rother, Russell P; Bell, Leonard; Hillmen, Peter; Gladwin, Mark T
- Abstract
The efficient sequestration of hemoglobin by the red blood cell membrane and the presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent the buildup of this molecule in the plasma. A growing list of clinical manifestations attributed to hemoglobin release in a variety of acquired and iatrogenic hemolytic disorders suggests that hemolysis and hemoglobinemia should be considered as a novel mechanism of human disease.
- Publication
JAMA, 2005, Vol 293, Issue 13, p1653
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.293.13.1653