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- Title
Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial.
- Authors
Wiegman, Albert; Hutten, Barbara A; de Groot, Eric; Rodenburg, Jessica; Bakker, Henk D; Büller, Harry R; Sijbrands, Eric J G; Kastelein, John J P
- Abstract
Children with familial hypercholesterolemia have endothelial dysfunction and increased carotid intima-media thickness (IMT), which herald the premature atherosclerotic disease they develop later in life. Although intervention therapy in the causal pathway of this disorder has been available for more than a decade, the long-term efficacy and safety of cholesterol-lowering medication have not been evaluated in children.
- Publication
JAMA, 2004, Vol 292, Issue 3, p331
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.292.3.331