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- Title
A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States.
- Authors
Lynch, Henry T; Coronel, Stephanie M; Okimoto, Ross; Hampel, Heather; Sweet, Kevin; Lynch, Jane F; Barrows, Ali; Wijnen, Juul; van der Klift, Heleen; Franken, Patrick; Wagner, Anja; Fodde, Riccardo; de la Chapelle, Albert
- Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is caused by mutations in the mismatch repair genes and confers an extraordinarily high risk of colorectal, endometrial, and other cancers. However, while carriers of these mutations should be identified, counseled, and offered clinical surveillance, at present the mutations are not tested for in mutation analyses.
- Publication
JAMA, 2004, Vol 291, Issue 6, p718
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.291.6.718