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- Title
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial.
- Authors
Tariot, Pierre N; Farlow, Martin R; Grossberg, George T; Graham, Stephen M; McDonald, Scott; Gergel, Ivan; Memantine Study Group
- Abstract
Memantine is a low- to moderate-affinity, uncompetitive N-methyl-D-aspartate receptor antagonist. Controlled trials have demonstrated the safety and efficacy of memantine monotherapy for patients with moderate to severe Alzheimer disease (AD) but no controlled trials of memantine in patients receiving a cholinesterase inhibitor have been performed.
- Publication
JAMA, 2004, Vol 291, Issue 3, p317
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.291.3.317