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- Title
Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial.
- Authors
Merten, Gregory J; Burgess, W Patrick; Gray, Lee V; Holleman, Jeremiah H; Roush, Timothy S; Kowalchuk, Glen J; Bersin, Robert M; Van Moore, Arl; Simonton, Charles A, 3rd; Rittase, Robert A; Norton, H James; Kennedy, Thomas P
- Abstract
Contrast-induced nephropathy remains a common complication of radiographic procedures. Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure. Acute renal failure from both ischemia and contrast are postulated to occur from free-radical injury. However, no studies in humans or animals have evaluated the efficacy of sodium bicarbonate for prophylaxis against contrast-induced nephropathy.
- Publication
JAMA, 2004, Vol 291, Issue 19, p2328
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.291.19.2328