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- Title
Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial.
- Authors
Szapary, Philippe O; Wolfe, Megan L; Bloedon, LeAnne T; Cucchiara, Andrew J; DerMarderosian, Ara H; Cirigliano, Michael D; Rader, Daniel J
- Abstract
Herbal extracts from Commiphora mukul (guggul) have been widely used in Asia as cholesterol-lowering agents, and their popularity is increasing in the United States. Recently, guggulsterones, the purported bioactive compounds of guggul, have been shown to be potent antagonists of 2 nuclear hormone receptors involved in cholesterol metabolism, establishing a plausible mechanism of action for the hypolipidemic effects of these extracts. However, there are currently no published safety or efficacy data on the use of guggul extracts in Western populations.
- Publication
JAMA, 2003, Vol 290, Issue 6, p765
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.290.6.765