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- Title
Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial.
- Authors
Nissen, Steven E; Tsunoda, Taro; Tuzcu, E Murat; Schoenhagen, Paul; Cooper, Christopher J; Yasin, Muhammad; Eaton, Gregory M; Lauer, Michael A; Sheldon, W Scott; Grines, Cindy L; Halpern, Stephen; Crowe, Tim; Blankenship, James C; Kerensky, Richard
- Abstract
Although low levels of high-density lipoprotein cholesterol (HDL-C) increase risk for coronary disease, no data exist regarding potential benefits of administration of HDL-C or an HDL mimetic. ApoA-I Milano is a variant of apolipoprotein A-I identified in individuals in rural Italy who exhibit very low levels of HDL. Infusion of recombinant ApoA-I Milano-phospholipid complexes produces rapid regression of atherosclerosis in animal models.
- Publication
JAMA, 2003, Vol 290, Issue 17, p2292
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.290.17.2292