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- Title
Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy.
- Authors
Shishehbor, Mehdi H; Aviles, Ronnier J; Brennan, Marie-Luise; Fu, Xiaoming; Goormastic, Marlene; Pearce, Gregory L; Gokce, Noyan; Keaney, John F, Jr; Penn, Marc S; Sprecher, Dennis L; Vita, Joseph A; Hazen, Stanley L
- Abstract
Formation of nitric oxide-derived oxidants may serve as a mechanism linking inflammation to development of atherosclerosis. Nitrotyrosine, a specific marker for protein modification by nitric oxide-derived oxidants, is enriched in human atherosclerotic lesions and low-density lipoprotein (LDL) recovered from human atheroma.
- Publication
JAMA, 2003, Vol 289, Issue 13, p1675
- ISSN
0098-7484
- Publication type
Journal Article
- DOI
10.1001/jama.289.13.1675