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- Title
Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.
- Authors
Steinberg, Martin H; Barton, Franca; Castro, Oswaldo; Pegelow, Charles H; Ballas, Samir K; Kutlar, Abdullah; Orringer, Eugene; Bellevue, Rita; Olivieri, Nancy; Eckman, James; Varma, Mala; Ramirez, Gloria; Adler, Brian; Smith, Wally; Carlos, Timothy; Ataga, Kenneth; DeCastro, Laura; Bigelow, Carolyn; Saunthararajah, Yogen; Telfer, Margaret; Vichinsky, Elliott; Claster, Susan; Shurin, Susan; Bridges, Kenneth; Waclawiw, Myron; Bonds, Duane; Terrin, Michael
- Abstract
Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidity and mortality.
- Publication
JAMA, 2003, Vol 289, Issue 13, p1645
- ISSN
0098-7484
- Publication type
Journal Article
- DOI
10.1001/jama.289.13.1645