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Title
Placebo response in studies of major depression: variable, substantial, and growing.
Authors
Walsh, B Timothy; Seidman, Stuart N; Sysko, Robyn; Gould, Madelyn
Abstract
Intense debate persists about the need for placebo-controlled groups in clinical trials of medications for major depressive disorder (MDD). There is continuing interest in the development of new medications, but because effective antidepressants are already available, ethical concerns have been raised about the need for placebo groups in new trials.