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- Title
Association between azithromycin therapy and duration of bacterial shedding among patients with Shiga toxin-producing enteroaggregative Escherichia coli O104:H4.
- Authors
Nitschke, Martin; Sayk, Friedhelm; Härtel, Christoph; Roseland, Rahel Tabea; Hauswaldt, Susanne; Steinhoff, Jürgen; Fellermann, Klaus; Derad, Inge; Wellhöner, Peter; Büning, Jürgen; Tiemer, Bettina; Katalinic, Alexander; Rupp, Jan; Lehnert, Hendrik; Solbach, Werner; Knobloch, Johannes K-M
- Abstract
An outbreak of Shiga toxin-producing enteroaggregative Escherichia coli (STEC O104:H4) infection with a high incidence of hemolytic uremic syndrome (HUS) occurred in Germany in May 2011. Antibiotic treatment of STEC infection is discouraged because it might increase the risk of HUS development. However, antibiotic therapy is widely used to treat enteroaggregative E coli infection. In the German outbreak, a substantial number of patients received prophylactic azithromycin treatment as part of a therapeutic regimen with the C5 antibody eculizumab.
- Publication
JAMA, 2012, Vol 307, Issue 10, p1046
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.2012.264