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- Title
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.
- Authors
Link, Daniel C; Schuettpelz, Laura G; Shen, Dong; Wang, Jinling; Walter, Matthew J; Kulkarni, Shashikant; Payton, Jacqueline E; Ivanovich, Jennifer; Goodfellow, Paul J; Le Beau, Michelle; Koboldt, Daniel C; Dooling, David J; Fulton, Robert S; Bender, R Hugh F; Fulton, Lucinda L; Delehaunty, Kimberly D; Fronick, Catrina C; Appelbaum, Elizabeth L; Schmidt, Heather; Abbott, Rachel; O'Laughlin, Michelle; Chen, Ken; McLellan, Michael D; Varghese, Nobish; Nagarajan, Rakesh; Heath, Sharon; Graubert, Timothy A; Ding, Li; Ley, Timothy J; Zambetti, Gerard P; Wilson, Richard K; Mardis, Elaine R
- Abstract
The identification of patients with inherited cancer susceptibility syndromes facilitates early diagnosis, prevention, and treatment. However, in many cases of suspected cancer susceptibility, the family history is unclear and genetic testing of common cancer susceptibility genes is unrevealing.
- Publication
JAMA, 2011, Vol 305, Issue 15, p1568
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.2011.473