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Title
Plasma clusterin and the risk of Alzheimer disease.
Authors
Schrijvers, Elisabeth M C; Koudstaal, Peter J; Hofman, Albert; Breteler, Monique M B
Abstract
Variants in the clusterin gene are associated with the risk of Alzheimer disease (AD) and clusterin levels have been found to be increased in brain and cerebrospinal fluid of patients with AD. Plasma clusterin was reported to be associated with brain atrophy, baseline disease severity, and rapid clinical progression in patients with AD.