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- Title
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.
- Authors
Bassler, Dirk; Briel, Matthias; Montori, Victor M; Lane, Melanie; Glasziou, Paul; Zhou, Qi; Heels-Ansdell, Diane; Walter, Stephen D; Guyatt, Gordon H; Flynn, David N; Elamin, Mohamed B; Murad, Mohammad Hassan; Abu Elnour, Nisrin O; Lampropulos, Julianna F; Sood, Amit; Mullan, Rebecca J; Erwin, Patricia J; Bankhead, Clare R; Perera, Rafael; Ruiz Culebro, Carolina; You, John J; Mulla, Sohail M; Kaur, Jagdeep; Nerenberg, Kara A; Schünemann, Holger; Cook, Deborah J; Lutz, Kristina; Ribic, Christine M; Vale, Noah; Malaga, German; Akl, Elie A; Ferreira-Gonzalez, Ignacio; Alonso-Coello, Pablo; Urrutia, Gerard; Kunz, Regina; Bucher, Heiner C; Nordmann, Alain J; Raatz, Heike; da Silva, Suzana Alves; Tuche, Fabio; Strahm, Brigitte; Djulbegovic, Benjamin; Adhikari, Neill K J; Mills, Edward J; Gwadry-Sridhar, Femida; Kirpalani, Haresh; Soares, Heloisa P; Karanicolas, Paul J; Burns, Karen E A; Vandvik, Per Olav; Coto-Yglesias, Fernando; Chrispim, Pedro Paulo M; Ramsay, Tim; STOPIT-2 Study Group
- Abstract
Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping.
- Publication
JAMA, 2010, Vol 303, Issue 12, p1180
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.2010.310