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- Title
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
- Authors
Shuldiner, Alan R; O'Connell, Jeffrey R; Bliden, Kevin P; Gandhi, Amish; Ryan, Kathleen; Horenstein, Richard B; Damcott, Coleen M; Pakyz, Ruth; Tantry, Udaya S; Gibson, Quince; Pollin, Toni I; Post, Wendy; Parsa, Afshin; Mitchell, Braxton D; Faraday, Nauder; Herzog, William; Gurbel, Paul A
- Abstract
Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous coronary intervention by inhibiting adenosine diphosphate (ADP)-dependent platelet activation. However, nonresponsiveness is widely recognized and is related to recurrent ischemic events.
- Publication
JAMA, 2009, Vol 302, Issue 8, p849
- ISSN
1538-3598
- Publication type
Journal Article
- DOI
10.1001/jama.2009.1232