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- Title
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy.
- Authors
Hasler, Gregor; van der Veen, Jan Willem; Tumonis, Toni; Meyers, Noah; Shen, Jun; Drevets, Wayne C
- Abstract
Increasing evidence indicates that major depressive disorder (MDD) is associated with altered function of the major excitatory and inhibitory neurotransmitters glutamate and gamma-aminobutyric acid (GABA), respectively. A recently developed magnetic resonance spectroscopy method allows for reliable measurement of glutamate/glutamine (Glx) and GABA concentrations in prefrontal brain regions that have been implicated in the pathophysiologic mechanisms of MDD by studies using other neuroimaging and postmortem techniques.
- Publication
Archives of general psychiatry, 2007, Vol 64, Issue 2, p193
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.64.2.193