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- Title
Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims.
- Authors
Dwivedi, Yogesh; Mondal, Amal C; Rizavi, Hooriyah S; Faludi, Gabor; Palkovits, Miklos; Sarosi, Andrea; Conley, Robert R; Pandey, Ghanshyam N
- Abstract
Depression is a major public health problem. Despite many years of research, the molecular mechanisms associated with depression remain unclear. Rap-1, activated in response to many extracellular stimuli, is one of the major substrates of protein kinase A, which participates in myriad physiologic functions in the brain, including cell survival and synaptic plasticity. Rap-1 is also activated directly by cyclic adenosine monophosphate through Epac, and thus participates in mediating physiologic functions independent of protein kinase A.
- Publication
Archives of general psychiatry, 2006, Vol 63, Issue 6, p639
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.63.6.639