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- Title
Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.
- Authors
Bartzokis, George; Lu, Po H; Geschwind, Daniel H; Edwards, Nancy; Mintz, Jim; Cummings, Jeffrey L
- Abstract
Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 alleles decrease and the APOE2 alleles increase age at onset of AD. Human and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begins breaking down, with an accelerating age-related trajectory most evident in the brain's later-myelinating association regions. This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD.
- Publication
Archives of general psychiatry, 2006, Vol 63, Issue 1, p63
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.63.1.63