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- Title
Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder.
- Authors
Thapar, Anita; Langley, Kate; Fowler, Tom; Rice, Frances; Turic, Darko; Whittinger, Naureen; Aggleton, John; Van den Bree, Marianne; Owen, Michael; O'Donovan, Michael
- Abstract
Early-onset antisocial behavior accompanied by attention-deficit/hyperactivity disorder is a clinically severe variant of antisocial behavior that is associated with a particularly poor outcome. Identifying early predictors is thus important. Genetic and prenatal environmental risk factors and prefrontal cortical function are thought to contribute. Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene.
- Publication
Archives of general psychiatry, 2005, Vol 62, Issue 11, p1275
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.62.11.1275