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- Title
Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study.
- Authors
Pandey, Ghanshyam N; Dwivedi, Yogesh; Rizavi, Hooriyah S; Ren, Xinguo; Conley, Robert R
- Abstract
Teenage suicide is a major public health concern. Although there is some understanding of the psychosocial factors associated with teenage suicide, little is known about the neurobiologic factors of teenage suicide. Protein kinase C (PKC) is a critical phosphorylating enzyme in the phosphoinositide signaling pathway (which is involved in many physiologic functions in the brain and has been implicated in the pathogenesis of mood disorders) and is also a target for the therapeutic action of mood-stabilizing drugs.
- Publication
Archives of general psychiatry, 2004, Vol 61, Issue 7, p685
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.61.7.685