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- Title
Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression.
- Authors
Murphy, Greer M, Jr; Hollander, Steven B; Rodrigues, Heidi E; Kremer, Charlotte; Schatzberg, Alan F
- Abstract
The "long/short"polymorphism (5HTTLPR) in the promoter of the serotonin transporter gene (SLC6A4) has been proposed as a pharmacogenetic marker for antidepressant efficacy. Some but not all studies have found that the short form of 5HTTLPR (S allele) results in decreased efficacy of selective serotonin reuptake inhibitors.
- Publication
Archives of general psychiatry, 2004, Vol 61, Issue 11, p1163
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.61.11.1163