We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses.
- Authors
Gogtay, Nitin; Sporn, Alexandra; Clasen, Liv S; Nugent, Tom F, 3rd; Greenstein, Deanna; Nicolson, Rob; Giedd, Jay N; Lenane, Marge; Gochman, Pete; Evans, Alan; Rapoport, Judith L
- Abstract
Recent anatomical brain magnetic resonance imaging (MRI) studies show a striking postpsychotic progressive loss of cortical gray matter (GM) in patients with childhood-onset schizophrenia (COS), which appears greater than that seen for adult patients. However, the diagnostic specificity and the relationship of these changes to drug treatment and cognitive functioning remain unclear. We performed a comparative prospective brain MRI study in patients with COS and pediatric patients with transient psychosis with behavior problems (psychosis not otherwise specified) provisionally considered multidimensionally impaired (MDI). We hypothesized that cortical GM loss would occur in patients with COS but not in adolescents with atypical psychoses.
- Publication
Archives of general psychiatry, 2004, Vol 61, Issue 1, p17
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.61.1.17