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- Title
A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices.
- Authors
Blumberg, Hilary P; Leung, Hoi-Chung; Skudlarski, Pawel; Lacadie, Cheryl M; Fredericks, Carolyn A; Harris, Brent C; Charney, Dennis S; Gore, John C; Krystal, John H; Peterson, Bradley S
- Abstract
Abnormalities in prefrontal and anterior cingulate cortices are implicated in disturbances of attention, cognition, and impulse regulation in bipolar disorder. Acute episodes have been associated with dysfunction in these brain regions, and more enduring trait-related dysfunction has been implicated by volumetric and cellular abnormalities in these regions. The relative contributions of prefrontal regions to state and trait disturbances in bipolar disorder, however, have not been defined. We sought to characterize state- and trait-related functional impairment in frontal systems in bipolar disorder.
- Publication
Archives of general psychiatry, 2003, Vol 60, Issue 6, p601
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.60.6.601