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- Title
Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia.
- Authors
Hashimoto, Kenji; Fukushima, Takeshi; Shimizu, Eiji; Komatsu, Naoya; Watanabe, Hiroyuki; Shinoda, Naoyuki; Nakazato, Michiko; Kumakiri, Chikara; Okada, Shin-ichi; Hasegawa, Hisanori; Imai, Kazuhiro; Iyo, Masaomi
- Abstract
The hypofunction of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors has been implicated in the pathophysiology of schizophrenia. Several lines of evidence suggest that D-serine may function as an endogenous agonist of the glycine site of the NMDA receptor. The aim of this study was to examine whether serum levels of D- and L-serine in patients with schizophrenia are different from those of healthy controls.
- Publication
Archives of general psychiatry, 2003, Vol 60, Issue 6, p572
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.60.6.572