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- Title
Alterations in stress cortisol reactivity in depressed preschoolers relative to psychiatric and no-disorder comparison groups.
- Authors
Luby, Joan L; Heffelfinger, Amy; Mrakotsky, Christine; Brown, Kathy; Hessler, Martha; Spitznagel, Edward
- Abstract
Despite the robust and widely replicated finding of elevated hypothalamic-pituitary-adrenal (HPA) axis reactivity in depressed adults, studies of depressed children have yielded ambiguous findings. Animal models of early depression and studies of children experiencing early psychosocial deprivation have suggested that alterations in HPA axis reactivity are evident in early "depressive-like" conditions. The current study is, to our knowledge, the first investigation of HPA axis reactivity in very young children with a clinical depressive syndrome for which content validity has been established.
- Publication
Archives of general psychiatry, 2003, Vol 60, Issue 12, p1248
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.60.12.1248