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- Title
Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study.
- Authors
Epperson, C Neill; Haga, Kristin; Mason, Graeme F; Sellers, Edward; Gueorguieva, Ralitza; Zhang, Wenjiang; Weiss, Erica; Rothman, Douglas L; Krystal, John H
- Abstract
There is increasing support for the hypothesis that gonadal steroids involved in the regulation of the human menstrual cycle modulate gamma-aminobutyric acid (GABA) neuronal function. This study tests the hypothesis that cortical GABA neuronal function, reflected in brain GABA concentrations, fluctuates across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder (PMDD) and that a menstrual cycle phase-dependent abnormality in brain GABA concentrations in women diagnosed as having PMDD would reflect altered central response to circulating gonadal and neuroactive steroids.
- Publication
Archives of general psychiatry, 2002, Vol 59, Issue 9, p851
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.59.9.851