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- Title
Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives.
- Authors
Seidman, Larry J; Faraone, Stephen V; Goldstein, Jill M; Kremen, William S; Horton, Nicholas J; Makris, Nikos; Toomey, Rosemary; Kennedy, David; Caviness, Verne S; Tsuang, Ming T
- Abstract
Clues to the causes of schizophrenia can be derived from studying first-degree relatives because they are genetically related to an ill family member. Abnormalities observed in nonpsychotic relatives are indicators of possible genetic vulnerability to illness, independent of psychosis. We tested 4 hypotheses: (1) that hippocampal volume is smaller in nonpsychotic relatives than in controls, particularly in the left hemisphere; (2) that hippocampi will be smaller in multiplex relatives as compared with simplex relatives, and both will be smaller than in controls; (3) that hippocampal volumes and verbal declarative memory function will be positively correlated; and (4) that hippocampi will be smaller in patients with schizophrenia than in their nonpsychotic relatives or in controls.
- Publication
Archives of general psychiatry, 2002, Vol 59, Issue 9, p839
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.59.9.839