We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuronal substrate of the saccadic inhibition deficit in schizophrenia investigated with 3-dimensional event-related functional magnetic resonance imaging.
- Authors
Raemaekers, Mathijs; Jansma, Johannus M; Cahn, Wiepke; Van der Geest, Josef N; van der Linden, Jeroen A; Kahn, René S; Ramsey, Nick F
- Abstract
Several studies have shown that the ability to suppress automatic saccadic eye movements is impaired in patients with schizophrenia as well as in their first-degree relatives, and suggest that this impairment is a potential vulnerability marker for schizophrenia. The neurobiological mechanisms underlying normal saccade production and inhibition, revealed in primate studies, indicate that the impairment may result from a failure of the oculomotor system to effectively exert inhibitory control over brainstem structures. Functional localization of the affected brain structure(s) potentially provides a physiological measure for the investigation of vulnerability markers in schizophrenia.
- Publication
Archives of general psychiatry, 2002, Vol 59, Issue 4, p313
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.59.4.313