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- Title
Brain volume changes in first-episode schizophrenia: a 1-year follow-up study.
- Authors
Cahn, Wiepke; Hulshoff Pol, Hilleke E; Lems, Elleke B T E; van Haren, Neeltje E M; Schnack, Hugo G; van der Linden, Jeroen A; Schothorst, Patricia F; van Engeland, Herman; Kahn, René S
- Abstract
Imaging studies of patients with schizophrenia have demonstrated that brain abnormalities are largely confined to decreases in gray matter volume and enlargement of the lateral and third ventricles. Global gray matter volume has been reported to progressively decrease in childhood-onset and chronic schizophrenia. Global gray matter volumes have not been examined longitudinally in patients with first-episode schizophrenia. One would expect global gray matter to decrease progressively, particularly in first-episode patients, because clinical deterioration is greatest in the early stages of the disease.
- Publication
Archives of general psychiatry, 2002, Vol 59, Issue 11, p1002
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.59.11.1002