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- Title
Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression.
- Authors
Zhou, J N; Riemersma, R F; Unmehopa, U A; Hoogendijk, W J; van Heerikhuize, J J; Hofman, M A; Swaab, D F
- Abstract
Circadian rhythm disturbances are frequently found in depressed subjects. Although it has been presumed that these disturbances may reflect a disorder of the circadian pacemaker, this has never been established. The suprachiasmatic nucleus (SCN) is the pacemaker of the circadian timing system in mammals, and arginine vasopressin (AVP) is one of its major neuropeptides. As peptide content is often taken as a measure for activity, we hypothesized that a decreased number of AVP-immunoreactive (AVP-IR) neurons and amount of AVP-messenger RNA (mRNA) would be present in the SCN of depressed subjects.
- Publication
Archives of general psychiatry, 2001, Vol 58, Issue 7, p655
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.58.7.655