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- Title
Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia.
- Authors
Barch, D M; Carter, C S; Braver, T S; Sabb, F W; MacDonald, A, 3rd; Noll, D C; Cohen, J D
- Abstract
Previously we proposed that dorsolateral prefrontal cortex (PFC) supports a specific working memory (WM) subcomponent: the ability to represent and maintain context information necessary to guide appropriate task behavior. By context, we mean prior task-relevant information represented in such a form that it supports selection of the appropriate behavioral response. Furthermore, we hypothesized that WM deficits in schizophrenia reflect impaired context processing due to a disturbance in dorsolateral PFC. We use functional magnetic resonance imaging to examine PFC activation in medication-naive, first-episode patients with schizophrenia during a WM, task-isolating context processing.
- Publication
Archives of general psychiatry, 2001, Vol 58, Issue 3, p280
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.58.3.280