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Title
Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.
Authors
Glantz, L A; Lewis, D A
Abstract
The pathophysiological characteristics of schizophrenia appear to involve altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer 3 pyramidal neurons play in corticocortical and thalamocortical connectivity, we hypothesized that the excitatory inputs to these neurons are altered in subjects with schizophrenia.
Publication
Archives of general psychiatry, 2000, Vol 57, Issue 1, p65